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KMID : 1084220150220060346
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Journal of Rheumatic Diseases
2015 Volume.22 No. 6 p.346 ~ p.355
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Depression and Quality of Life in Patients with Systemic Lupus Erythematosus
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Chang Sung-Hae
Cho Ja-Hyun
Shin Na-Hee
Oh Hye-Jin
Choi Byoong-Yong
Yoon Myeong-Jae
Lee Eun-Young
Lee Eun-Bong
Lee Yun-Jong
Lee Tae-Jin
Hahm Bong-Jin
Song Young-Wook
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Abstract
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Objective. The objective of this study is to examine the prevalence of depression and its related factors including quality of life, brain-derived neurotrophic factor (BDNF), and vitamin D in patients with systemic lupus erythematosus (SLE).
Methods. Depression was assessed using the center for epidemiologic studies depression (CES-D) scale. Disease activity, disease-related organ damage, the EuroQol-5 dimensions (EQ-5D), sociodemographic features, and laboratory tests including serum vitamin D level were surveyed. Serum BDNF was measured using an enzyme-linked immunosorbent assay.
Results. Depression was observed in 22.8% of 180 SLE patients (n=41). Patients with marital status of single/divorced/separated/widowed, a higher patient global assessment (PGA) score, and extreme pain/discomfort showed significant association with depression. The EQ-5D index showed negative correlation with CES-D score (r=?0.56, p＜0.05). In each EQ-5D dimension, depression showed significant association with moderate to severe problems in self-care and usual activities, and extreme pain/discomfort. Serum BDNF levels were not associated with depression (p=0.75) but associated with SLE disease activity index (SLEDAI; r=?0.21, p＜0.05). Serum vitamin D levels were not associated with depression (p=0.60) but showed negative correlation with SLEDAI (r=?0.23, p＜0.05) and mean glucocorticoid dose over the previous 3 months (r=?0.21, p＜0.05) after adjustment for use of vitamin D supplement.
Conclusion. Depression was prevalent in patients with SLE and was associated with low quality of life, and a higher PGA but not with SLEDAI. Serum BDNF and vitamin D levels were not associated with depression but showed negative correlation with SLEDAI.
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KEYWORD
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Systemic lupus erythematosus, Depression, Quality of life, Brain-derived neurotrophic factor, Vitamin D
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